WWP2 widely expressed [25] and played a crucial part in pathogenesis in different types of tumors such as lung cancer, gastric cancer and liver cancer by regulating ubiquitin-dependent degradation of substrate proteins [14, 15, 26] In our study, we firstly analyzed ubiquitin ligase WWP2 expression level in ALL patients and the relationship with clinicopathological factors. This evidence concerns the gene WWP2 and acute lymphoblastic leukemia.