A nanogel formed by cholesteryl pullulan (named CHP, 25 nm in diameter[151]) was well examined in protein antigen delivery, and the resulting CHP‐antigen vaccine formulations were capable of targeting APCs and inducing antigen specific T cell immunity against murine tumor.[152] A protein cancer vaccine of CHP‐HER2 was assessed in a clinical study in patients with HER2+ cancers, showing clinical response with HER2‐specific T cell immunity.[153] Vaccination of patients with CHP‐NY‐ESO‐1 vaccine also induced antigen specific T cell response[154] (Table 2). This evidence concerns the gene ERBB2 and cancer.