Chen lab designed a multifunctional nanoformulation (≈145 nm), which comprised 1) magnetic iron oxide nanoparticles for tumor accumulation under an external magnetic field; 2) fucoidan with inherent therapeutic effect and immunostimulatory functions; 3) aldehyde‐dextran for conjugation of anti‐PD‐L1 mAbs (checkpoint inhibition) and anti‐CD3/CD28 mAbs (T cell activation).[86] Post intravenous administration, this multiple functional nanoformulation augmented effector T cell mediated anti‐tumor and anti‐metastatic capabilities in 4T1 and CT‐26 tumor models. This evidence concerns the gene CD28 and neoplasm.