Similar to HNF1A, for individuals with a HNF4A pathogenic variants (Tables S3 and S7), the age-related penetrance of diabetes was lower in the family members, the Geisinger cohort and the UK Biobank compared to MODY probands (log rank test, all p < 8 × 10−11; Figures 2A and S5). This evidence concerns the gene HNF1A and diabetes mellitus.