Kaplan-Meier analysis demonstrated that the penetrance of diabetes for pathogenic HNF1A variants was lower in the family members, the Geisinger cohort, and UK Biobank compared to the HNF1A-MODY probands (log rank test, all p < 3 × 10−9; Figures 1A and S1). The gene discussed is HNF1A; the disease is diabetes mellitus.