Similar to HNF1A, for individuals with a HNF4A pathogenic variants (Tables S3 and S7), the age-related penetrance of diabetes was lower in the family members, the Geisinger cohort and the UK Biobank compared to MODY probands (log rank test, all p < 8 × 10−11; Figures 2A and S5). The gene discussed is HNF4A; the disease is diabetes mellitus.