In the aggregate of the three commonest genes for MODY, approximately 1:2,100 (95%CI 1:2,700 to 1:1,640) and 1:1,500 (1:1,750 to 1:1,250) individuals harbor a pathogenic variant for HNF1A, HNF4A, or GCK in the Geisinger and UK Biobank population cohorts, respectively. This evidence concerns the gene HNF4A and MODY.