All in all, the pathogenic IL-6/IL-23/Th17 axis, which may be induced by microbiota, contributes to neurocognitive deficits and the phenome of schizophrenia, especially MNP, due to its key role in peripheral inflammation, gut and BBB permeability, neuroinflammation and ensuing neurotoxic effects on CNS circuits. The gene discussed is IL37; the disease is schizophrenia.