Interestingly, SB-HTVI of c-Met and single-guide RNA (sgRNA) of Axin1 (sgAxin1), which has been shown to induce HCC but not GS expression (27), induced HCC to a similar extent in both WT and Glul-KO livers (Supplemental Figure 1, M and N). Here, APC is linked to hepatocellular carcinoma.