Oncogenes also led to increased levels of ammonia in the plasma (Figure 4F) and in tumor interstitial fluid by both c-Met/ΔN90-β-catenin and YAP/ΔN90-β-catenin (Figure 4G), which were further increased in the Glul-KO mice (Figure 4, F and G). This evidence concerns the gene MET and neoplasm.