While DEN treatment led to a similar extent of DNA damage response and growth signaling in the WT and Glul-KO livers (Supplemental Figure 1F), Glul-KO mice displayed markedly increased tumor burden and cell proliferation upon treatment with DEN together with phenobarbital (PB) or a high-fat diet (HFD) (Supplemental Figure 1, G–J). Here, GLUL is linked to neoplasm.