MET and hepatocellular carcinoma: To determine the role of GS in liver cancer, we used the sleeping beauty transposon and hydrodynamic tail vein injection (SB-HTVI) system to deliver c-Met and the constitutively active N-terminal deletion mutant of β-catenin (ΔN90-β-catenin), which has been characterized to induce HCC (23, 24).