CCR2 and pancreatic neoplasm: Histological examination of pancreatic tumors from early-stage (10–11 weeks old) KPC and KPC-CCR2–/– mice showed that KPC-CCR2–/– mice had more disease-free normal pancreatic tissue and lower-grade PanINs than the KPC group (Figure 4C), consistent with the right-shifted survival curve (Figure 4B), suggesting a slower progression of disease.