For instance, targeted depletion of granulocytic MDSCs in autochthonous PDA in KPC mice increases the intratumoral accumulation of activated CD8+ T cells (16), while partial activation of CD11b leads to TAM repolarization, a reduction in immunosuppressive myeloid cells, and enhanced DC responses to improve antitumor T cell immunity (14). The gene discussed is ITGAM; the disease is Patent ductus arteriosus.