To examine how well human PDA TAMs are represented in various murine models of PDA, we extended our investigation to the analysis of scRNA-Seq data from 3 different genetically engineered murine models of PDA: the KIC (KrasLSL-G12D/+ Ink4afl/fl Ptf1aCre/+), KPC (KrasLSL-G12D/+ Trp53LSL-R172H/+ Ptf1aCre/+), and KPfC (KrasLSL-G12D/+ Trp53fl/fl Pdx1-Cre) systems (Figure 2), as described previously (32). This evidence concerns the gene PDX1 and Patent ductus arteriosus.