Consistent with human data, murine PDA TAMs displayed high expression of M2-associated and immunosuppressive transcripts, such as Spp1, C1qb, Arg1, Tgfb1, and multiple MHCII molecules (e.g., H2-Aa, H1-Ab1, H2-Dma, H2-Dmb1, H2-Dmb2, and H2-Eb1; Figure 2 and Supplemental Figure 2). Here, SPP1 is linked to Patent ductus arteriosus.