For instance, by searching MADET with the keyword “Fusobacterium nucleatum,” we are able to see that the bacterial species F. nucleatum is negatively associated with the decreased anticancer effects of 5-FU chemotherapy for colorectal cancer (25) as well as positively related to the promoted efficacy of PD-L1 blockade on the other hand (19). This evidence concerns the gene CD274 and colorectal cancer.