Alternatively, a higher EXO1 expression or activity will induce the increase of recombination rate, impaired repair of DNA double-strand breaks, telomere resection and activation of Ras/PI3K signaling pathway, which may also further increase the cancer susceptibility (Liberti and Rasmussen, 2004; Muthuswami et al., 2013). This evidence concerns the gene EXO1 and cancer.