Through stressing the ZIC collection with doxorubicin, an anti-cancer drug, we demonstrated that novel genetic factors of doxorubicin-induced cardiomyopathy (DIC), such as Dnaj (Hsp40) homology, subfamily B, member 6b (dnajb6b), sorbin and SH3 domain-containing 2b (sorbs2b) and retinoid x receptor alpha a (rxraa), could be successfully identified (Ding et al., 2016; Ding et al., 2020b; Ma et al., 2020). Here, DNAJB6 is linked to cardiomyopathy.