In particular, the proportion of Ly6c2-hi Th1 and Lag3-hi Th1 cell subsets were dramatically reduced (by ~50%) during LCMV Cl13 as compared to LCMV Armstrong infection; this reduction in Th1 cell formation was accompanied by increased frequencies of Slamf6-hi, pre-Tfh, ISG, and Slamf7-hi clusters, whereas GC Tfh2 and Tfh1 clusters remained similar between infections (Figure 4A–B). The gene discussed is SLAMF6; the disease is infection.