GZMK and autoimmune disease: On the other hand, cluster 7 cells displayed uniquely high expression of Slamf7, Eomes, and Gzmk (Figure 1E, Figure 1—figure supplement 1A), and as such, cells within this cluster bore a resemblance to a cytolytic CD4+ T cell subset that has been identified in tumors as well as autoimmune disease (Della-Torre et al., 2018; Cachot et al., 2021).