(A) A canonical correlation analysis (CCA) was performed on single cell RNA-sequencing (scRNA-seq) libraries obtained from GP66-specific CD4+ T cells during chronic lymphocytic choriomeningitis virus (LCMV) Clone 13 (Cl13) infection (this study) and acute LCMV Armstrong infection (Khatun et al., 2021) that were integrated together using the integration function in Seurat (Butler et al., 2018). Here, CD4 is linked to infection.