CD4 and viral infectious disease: Notably, module score analysis demonstrated that most CD4+ T cell clusters from chronic LCMV infection exhibited decreased expression of the Th1-associated program, possibly suggesting that an attenuation in Th1-like activity is a broad feature of CD4+ T cells responding to chronic viral infection and not only a result of a decrease in the Th1 lineage (Figure 4C, Figure 4—figure supplement 1F).