LAG3 and infection: Conversely, Tfh module scores were generally similar between acute and chronic LCMV CD4+ T cell clusters, although the Ly6c2-hi Th1 and Lag3-hi Th1 cell subsets from chronic LCMV infection did display a relatively increased Tfh signature compared to their acute infection counterparts (Figure 4D, Figure 4—figure supplement 1F).