Placing the gene expression profiles from all human in vitro iPSC-microglia challenges and all in vitro mouse microglia challenges considered in this study onto this disease model axis singled out the expression changes invoked by LPS in mouse and LPS+IFN-γ in human iPSC-microglia as the challenge that distinctively produces a gene expression reaction similar to that shared among AD genetic mouse models (Fig. 6). This evidence concerns the gene IFNG and Alzheimer disease.