To approach the clinical evidence of the role of DNA damage and DDR in SARS‐CoV‐2 infection during aging, we analyzed the expression of ACE2, γH2AX, and p‐c‐Jun in healthy human small intestinal tissues isolated from old (60–73 years old) and young (31–50 years old) patients with stomach cancers or right‐sided colon cancers. Here, ACE2 is linked to gastric cancer.