Finally, to explore the biological function of SE at BCL2L1 gene loci, we performed experiments and found that the SAM system targeting individual SE peaks of BCL2L1 significantly facilitated cellular proliferation, migration and invasion, while the dCas9‐KRAB repressor complex resulted in contrast results in CRC (Figure S4H,I). Here, BCL2L1 is linked to colorectal carcinoma.