CDK12 and colorectal carcinoma: In addition, higher mRNA and protein levels of CDK12 were found in the CRC cells without metastatic capabilities (HCT116 and HCT8) and CRC cells with metastatic capabilities (COLO205 and SW620) relative to human normal colonic epithelial cells (NCM460 and HCoEpiC) (Figure 2H,I).