Figure 2 shows that the upstream regulators significantly predicted to be activated between HAE Type 1 flares versus controls and HAE Type 1 flares versus HAEnCI were TNF, IL1β, IL1A, IL18, TNFSF12, CSF2, TGFβ1, IL4, C5, IL17α, MIF, and TREM1; regulators predicted to be inhibited in these samples were COL18A1, FBN1, TP53, and IL10. The gene discussed is IL18; the disease is hereditary angioedema.