By gene network function and molecular integration analyses, we classified the DEPs into the following 10 clusters: AD, platelet activation, neutrophil degranulation, VEGFA–VEGFR2 signaling pathway, EGF/EGFR signaling pathway, lipid metabolism pathway, fatty acid biosynthesis, glucagon signaling pathway, MAPK signaling pathway, and IL‐18 signaling pathway (Figure 5, red represents increased, blue represents decreased, and the inner and outer circles represent platelets and TC brain regions), all of which were closely related to neurological diseases including AD.21, 22, 23, 24, 25, 26. Here, IL18 is linked to Alzheimer disease.