By integrating brain and platelet data, we identified the disordered networks highly associated with AD, such as platelet activation, interleukin‐18 (IL‐18) signaling pathway, and epidermal growth factor/epidermal growth factor receptor (EGF/EGFR) signaling pathway, by which high‐confidence targets throughout the center and periphery of AD were deduced. Here, EGFR is linked to Alzheimer disease.