To explore the driving molecules for changed central or peripheral networks in AD, we adopted weighted correlation network analysis (WGCNA) to analyze the relationships of the subjects' common diseases, including age, sex, MMSE score, basic diseases such as hypertension and coronary heart disease, AD pathology such as Aβ, high‐risk gene APOE, with DEPs observed by brain and platelet omics. The gene discussed is APOE; the disease is hypertensive disorder.