VHL and neoplasm: Clear cell RCC is the most common type of RCC and is rich in vascular networks induced by dysregulation of the VHL/HIF pathway, which provides a scientific rationale for developing VEGFR‐focused multikinase inhibitors (sorafenib, sunitinib, pazopanib, axitinib, cabozantinib, lenvatinib, and tivozanib) in this tumor type.475, 674, 676, 677