To explore the role of LOXL2 in the development of HCC progression, we first analyzed the expression level of LOXL2 in 18 types of cancer based on the TCGA database, which found that LOXL2 was markedly upregulated in 16 cancer types, including BLCA, BRCA, CHOL, COAD, ESCA, GBM, HNSC, KIRC, KIRP, LIHC, LUAD, LUSC, READ, STAD, THCA, and UCEC and was significantly downregulated in PRAD. The gene discussed is LOXL2; the disease is hepatocellular carcinoma.