AQP3 was expressed at lower levels in clear cell renal cell carcinoma (fold change = −3.889), chromophobe renal cell carcinoma (fold change = −1.887, Jones Renal, −5.181, Higgins Renal), papillary renal cell carcinoma (fold change = −8.716, Jones Renal, −9.131, Higgins Renal), nonhereditary clear cell renal cell carcinoma (fold change = −3.699), hereditary clear cell renal cell carcinoma (fold change = −2.391), renal oncocytoma (fold change = −13.367), and clear cell sarcoma of the kidney (fold change = −8.523) versus corresponding normal samples. This evidence concerns the gene AQP3 and chromophobe renal cell carcinoma.