AQP2 was expressed at lower levels in ccRCC (fold change = −4.592, Jones Renal, −13.183, Yusenko Renal, −5.590, Gumz Renal, -2.567, Lenburg Renal), renal Wilms tumor (fold change = −26.722), chromophobe renal cell carcinoma (fold change = −4.758, Jones Renal, −13.013, Yusenko Renal), renal oncocytoma (fold change = −21.537), papillary renal cell carcinoma (fold change = −4.945, Jones Renal, −14.794, Yusenko Renal), nonhereditary clear cell renal cell carcinoma (fold change = −11.212), and hereditary clear cell renal cell carcinoma (fold change = −12.336) versus corresponding normal samples. This evidence concerns the gene AQP2 and clear cell renal carcinoma.