As shown in Figure 8A, the percentages of genetic alterations in AQPs of ccRCC ranged from 0.2 to 5% for single genes (MIP, 2.4%, AQP1, 5%, AQP2, 2.2%, AQP3, 2%, AQP4, 4%, AQP5, 3%, AQP6, 0.8%, AQP7, 5%, AQP8, 0.2%, AQP9, 4%, AQP10, 0.4%, AQP11, 2.5%). This evidence concerns the gene AQP9 and nonpapillary renal cell carcinoma.