In conclusion, this NMA demonstrated that ivermectin/doxycycline, C-IVIG, methylprednisolone, IFN-β/SOC, IFN-β-1b, CP, remdesivir, LPV/r, IG, HS, auxora, and imatinib were effective for treating severe COVID-19 patients. Here, IFNB1 is linked to COVID-19.