VEGF, one of the most important inducers of angiogenesis and vascular permeability, also has a strong link with inflammation and immunity[23,24] and can greatly change the tissue microenvironment and induce inflammation.[25,26] Contrary to the sharp rise in VEGF levels in APAC eyes, VEGF remained at a slightly higher level in the CACG eyes, indicating a hypoxic microenvironment in the anterior segment tissues of the CACG and the APAC eyes. This evidence concerns the gene VEGFA and aldosterone-producing adrenal cortex adenoma.