The levels of tumor necrosis factor-alpha (TNF-α) (P = .0463), IL-8 (P = .0077), matrix metalloproteinase-2 (MMP-2) (P < .01), interferon-gamma (IFN-γ) (P = .0002), monocyte chemotactic protein-1 (MCP-1) (P = .0281), and tissue inhibitor of metalloproteinases-1 (TIMP-1) (P = .0004) were significantly elevated in the AH of patients with CACG, whereas IL-8 concentrations in the AH of patients with POAG were significantly higher (P = .0424). This evidence concerns the gene IFNG and open-angle glaucoma.