The AH levels of TNF-α (P < .0001), IL-8 (P = .0024), IL-6 (P = .0011), MMP-2 (P = .0115), IFN-γ (P < .0001), MCP-1 (P < .0001), vascular endothelial growth factor (VEGF) (P = .0194), and tissue inhibitor of metalloproteinases-1 (TIMP-1) (P < .0001) were significantly higher in the APAC group than those in the CG. This evidence concerns the gene VEGFA and aldosterone-producing adrenal cortex adenoma.