The mean concentrations of TNF-α (P < .001), IL-6 (P = .0048), IL-8 (P < .001), MMP-2 (P = .0002), MCP-1 (P < .0001), VEGF (P = .0073), TIMP-1 (P < .0001), and IFN-γ (P < .0001) were significantly lower in the POAG group than those in the APAC group. This evidence concerns the gene VEGFA and open-angle glaucoma.