KIR3DL3 may affect the function of NK cells through genetic differentiation, thus participating in the pathogenesis of BD.[47]NCR3 encodes NKp30,[48] which can initiate an activation signal cascade in NK cells, leading to cytokine production or cytotoxicity.[49] NK cells are a subgroup of lymphocytes. This evidence concerns the gene KIR3DL3 and Behcet disease.