Clinical studies have demonstrated that combined cyclosporine and prednisone therapy can down-regulate NK-like effector function of CD8 (bright) CD56 + T cells in patients with NIU.[33] Lipid mediators in the arachidonic acid signaling pathway are closely associated with intraocular inflammation, and drug intervention in the synthesis of lipid mediators may be of great significance in the treatment of uveitis.[21]. The gene discussed is CD8A; the disease is uveitis.