GDNF and Parkinson disease: In a word, acupuncture treatments in animal experiments have generated valuable mechanistic insights into the pathology of Parkinson and have provided evidence that acupuncture therapy is neuroprotective and can increase various neuroprotective agents such as brain-derived neurotrophic factor, glial cell- derived neurotrophic factor, and cyclophilin A, enhancing both anti-inflammatory and antioxidant activities.