PLEK and neoplasm: XIAP gene is overexpressed in many tumor cell lines, and its expression is closely related to tumor progression, recurrence, prognosis, and treatment resistance.[17] Phophatidylinositol-3-kinase (PI3K) is a crucial signaling center in immune cells that catalyzes the conversion of PIP2 to PIP3 and thus facilitates membrane recruitment of molecules containing PIP3-binding Pleckstrin homology domains such as the AKT, PDK1, Tec family kinases, adapter molecules, guanine nucleotide exchange factors, and GTPase-activating proteins.