The meta-analysis indicated that LCZ696 was associated with a significant reduction in all-cause mortality (hazard ratio [HR] = 0.84; 95% confidence interval [CI], 0.76–0.93; P = .0005), rate of hospitalizations for HF (HR = 0.80; 95% CI, 0.73–0.87; P < .00001), reduction in NT-proBNP levels (rate ratio = 0.78; 95% CI, 0.70–0.88; P < .0001), and decline in renal function (odds ratio = 0.77; 95% CI, 0.68–0.88; P < .0001) compared with ACEis and ARBs. The gene discussed is NPPB; the disease is hydrops fetalis.