Moreover, it has a poor tolerance.[22–24] By comparison, LCZ696 inhibits ARBs and enkephalinase, which increases the levels of natriuretic peptide, bradykinin, adrenomedullin, and other endogenous vasoactive peptides.[10,25,26] The advent of the angiotensin receptor neprilysin inhibitor, LCZ696, brings new hope for HF patients. This evidence concerns the gene ADM and hydrops fetalis.