Thus, it needs early intervention.[1,2] The treatment concept of HF continues to change from the hemodynamic stage in the 1970s to the neuroendocrine stage in the 1990s to the current stage of overall regulation and multi-target action.[3–5] The Golden Triangle drugs include angiotensin-converting enzyme inhibitors (ACEis), angiotensin-receptor blockers (ARBs), and aldosterone receptor antagonists β. This evidence concerns the gene ACE and hydrops fetalis.