PIP and cancer: GATA-3 has an important role in tumorigenesis.[26] Mazoujian et al reported that approximately 55% of breast cancers are positive for gross cystic disease fluid protein-15 (GCDFP-15) and that 90% of them are invasive lobular carcinomas.[27] Haiyan Liu et al performed immunohistochemical evaluation of GATA-3 expression in 1110 cases of cancer and 310 normal tissues.