Because of its critical function in cell cycle regulation, CDC25 is an excellent target for cancer treatment.[47,48] GPI anchor attachment 1 (GPAA1) can attach the GPI anchor to the ER protein and has been reported to promote EGFR-ERBB2 dimerization, which is advantageous to cancer metastasis and progression, as it promotes the expression of cancer-associated GPI-anchored proteins and provides a more stable platform for EGFR-ERBB2 dimerization (lipid rafts).[49]. This evidence concerns the gene GPAA1 and cancer.