ACE and diabetes mellitus: In the early stages of diabetes, ACE2 is upregulated and downregulated during the late stages.[19] This experiment showed that compared with the <1 year group and the 1 to 5 year group, the levels of ACE2 and Ang1-7 in the 5 to 10 year group and >10 year group were lower, while the levels of FBG, 2hPBG, ACE, AngII, IL-6, and CRP were higher.