Xue et al suggested that the ABCC2 rs717620 polymorphism is associated with resistance to ASMs among Uygur patients with epilepsy.16 In addition, Chen et al17 discovered that in a subgroup of generalized seizure, ABCC2 rs3740066 CC carriers had a higher frequency of valproic acid resistance than TC + TT carriers (P < 0.05). This evidence concerns the gene ABCC2 and Generalized-onset seizure.