ABCC2 and epilepsy: Single nucleotide polymorphisms (SNPs) of ABCC2 can influence the expression and function of the resultant proteins and are likely associated with drug resistance among patients with epilepsy.13 The most studied SNPs in this gene include 1249G>A (rs2273697) and −24C>T (rs717620).14 Grewal et al15 revealed that altered functionality of ABCB1 and ABCC2 can affect the disposition and bioavailability of ASMs, thereby interfering with antiseizure medication therapy.