Subsequently, based on the TCGA-STAD and GSE84437 datasets, 10 early-specific mRNA prognostic signature was constructed, including FERMT2, SLC52A3, TMTC1, GRP, AKAP12, GDF6, SLITRK4, NUDT11, RECK, and MAGEH1, which were associated with tumor size and stage. This evidence concerns the gene GDF6 and neoplasm.