The overexpression of miR-493-5p, a miRNA that acts as a mediator of PARP inhibitor (including olaparib and rucaparib) resistance, is relevant to the preservation of replication fork stability that results from the diminished nuclease activity of MRE11, CHD4, and EXO1 evident exclusively in BRCA2-mutated ovarian carcinomas [146]. The gene discussed is PARP1; the disease is ovarian carcinoma.