Flierl et al. [9] gave anti-IL-17A immediately after establishing a mouse model of severe CLP sepsis, and the 7-day survival rate of the mice increased to 58% compared with the 8% survival rate of the control mice treated with IgG, demonstrating that in the severe CLP model (the 7-day mortality rate was 100%) by neutralizing IL-17A successfully reduced mortality in mice. Here, IL17A is linked to Sepsis.