As previously reported, autologous gene-corrected keratinocytes expressing full-length C7 using a retroviral vector (EB-101, previously named LZRSE-COL7A1 Engineered Autologous Epidermal Sheets [LEAES]) were developed to treat chronic open wounds in patients with severe RDEB in the first gene therapy trial for RDEB (ClinicalTrials.gov, NCT01263379) [10, 11]. This evidence concerns the gene COL7A1 and recessive dystrophic epidermolysis bullosa.