Tezepelumab is an IgG2 monoclonal antibody that targets thymic stromal lymphopoietin (TSLP), preventing its interaction with the heterodimeric TSLP receptor, and impacting both type-2 and non-type 2 inflammatory pathways, including allergic, eosinophilic inflammation, and airway hyperresponsiveness. This evidence concerns the gene TSLP and airway hyperresponsiveness.