Moreover, in an animal study, rats were fed with amylose (low GI starch) showed larger adipocyte diameter, increased Glut 4 gene expression in fat tissue, increased glucose incorporation to lipids, and developed obesity, compared to rats fed with amylopectin (high GI starch) [51]. The gene discussed is SLC2A4; the disease is obesity due to melanocortin 4 receptor deficiency.