As revealed by IHC staining analysis, the proteins of CYBB, IL1A, IL1B, and SLC25A5 were mainly found in cancer cells’ nucleus, cytoplasm, and membranes; brown staining indicated positive staining (Fig. 8G, H, K, L,O, P, S, T); and these NRG proteins were either weakly expressed or not expressed in normal tissues (Fig. 8E, F, I, J, M, N, Q, R). The gene discussed is IL1B; the disease is cancer.