TNF and neoplasm: These inflammatory cells secrete pro-inflammatory cytokines like IL-1, IL-6, IL-15, IL-17, IL-23, tumor necrosis factor-α (TNF-α), and other molecules like IFN-γ, reactive oxygen species (ROS), serine and cysteine proteases, matrix metalloproteinases and membrane-perforating agents which are cytotoxic to tumor cells.