It was further detected that the addition of selenium nanoparticles significantly up-regulated the expression of various selenoproteins such as SELK, SELO, SELP, SelR, SELES, SELT, SELW, Gpx2, TrxR1 and Sep15 in cells, thus enhancing the anti-tumor effect of immune cell therapy [10]. Here, SELENOS is linked to neoplasm.