By analyzing the TCGA database we found that SELENBP1 expression in CRC was associated with DNA methylation sites such as cg17759475 (r = − 0.42, P < 0.001), cg16911672 (r = − 0.47, P < 0.001), cg07680533 (r = − 0.300, P < 0.001) cg24486037 (r = − 0.230, P < 0.001), cg26065909 (r = − 0.270, P < 0.001), cg24480379 (r = − 0.270, P < 0.001), and cg18515587 (r = − 0.480, P < 0.001), with a significant negative correlation in methylation (Fig. 5e–k). Here, SELENBP1 is linked to colorectal carcinoma.