FH and neoplasm: By using integrative bioinformatics assessment of both the tumour infiltrate (IIL, IIH) and the function of its component cells (FL, FH), we were able to identify 4 different tumour immune microenvironment profiles in our cohort, namely, IIL-FL, IIL-FH, IIH-FL and IIH-FH (Fig. 3a).