The HRD threshold of ≥33 captures 99% of known BRCA1- and/or BRCA2-deficient ovarian cancers, whereas the HRD score of ≥42 captures 95% of known BRCA1- and/or BRCA2-deficient ovarian cancers27, but cutoffs are less well defined for other tumor types. The gene discussed is BRCA1; the disease is neoplasm.