In the case of 48 genes correlating to both Cntnap2 KO mice and ASD patients, 36 downregulated genes were significantly associated with SV function (synaptic vesicle, synaptic membrane, and secretory vesicle) and neuronal axon (axon development, axon terminus, and neuron projection) (Fig. 4f, green, and Supplementary Table S9); these functions are pivotal for maintaining synaptic function and neuronal migration, and their dysregulation can lead to synaptic dysfunction [34] and neuronal migration deficits [35], which have been linked to NDDs [35], such as ASD and intellectual disabilities. This evidence concerns the gene CNTNAP2 and Intellectual disability.