For the expanded SD GWAS meta-analysis using 3765 cases and 6572 populational controls genotyped (Table 1 and Supplementary Method S1), one locus in neuroligin 1 (NLGN1) passing genome-wide significance threshold for SD meta-analysis compared to the general population was identified (top SNP rs73182688, with p = 5.48 × 10−8 before and p = 4.55 × 10−8 after mtCOJO analysis conditioning on MDD summary statistics (Table 2); Manhattan plots in Fig. 1A and Supplementary Fig. S3A, QQ-plots in Supplementary Fig. S2A, B). The gene discussed is NLGN1; the disease is major depressive disorder.