Furthermore, we found that M1 macrophages and CD4 + and CD8 + T cells showed higher infiltration in patients with CRC of the low-risk subgroup, whereas M2 macrophages and regulatory T cells had higher infiltration in the high-risk subgroup, which may further exacerbate the immune depletion status of patients of the high-risk group. The gene discussed is CD4; the disease is colorectal carcinoma.