To assess the clinical impact of cholesterol biosynthesis on breast cancer metastasis and NETs, we examined HMGCR, CCDC25 and H3cit expression by IHC staining in a tissue array, including 11 normal and paracancerous breast tissues, 27 primary breast cancer tissues and 17 metastatic tissues (Fig. 8a,b). This evidence concerns the gene HMGCR and breast carcinoma.