TP53BP2 and cancer: Staining with cell-impermeable DNA dye SytoxGreen also showed stronger NETs formation in ASPP2 depleted MDA-MB-231 cells than in control cells (Fig. 2d), which could be blocked by simvastatin, BBR and DNase I. These data suggest that cholesterol biosynthesis promotes invasive ability of cancer cells and the ability to form NETs with neutrophils.