Free and total cholesterol level, HMGCR mRNA, were significantly increased by ASPP2 depletion in cancer cells (Figs. 1a,b, and S2), which could be blocked by simvastatin and BBR, a new cholesterol-lowering drug that enhances LDLR expression or increases phosphorylation of HMGCR35,36. This evidence concerns the gene LDLR and cancer.