HMGCR and metastatic malignant neoplasm: However, the expression of HMGCR was positively correlated with the expression of CCDC25 and H3cit in 44 primary and metastatic cancer tissues (P < 0.05; Fig. 8b), and the expression of CCDC25 and H3cit was also positively correlated (P < 0.05; Fig. 8b).