Though no statistical relationships between HMGCR, CCDC25, H3cit expression and clinical features were found in 27 primary breast cancer patients, probably due to the limitation of tissue amount, the expression of CCDC25 was positively correlated with the expression of HMGCR and H3cit in 44 primary and metastatic cancer tissues, and the average IHC scores of CCDC25 was significantly higher in metastatic tissues than that in primary cancer tissues. Here, HMGCR is linked to breast cancer.