SIRT5 knockdown significantly enhanced the proportion of CRC cells in the G2/M and S phases and also increased the number of apoptotic cells, whereas exogenously supplied nucleosides decreased cell cycle arrest (Fig. 3a, b, and Supplementary Fig. 3i, j) and apoptosis (Fig. 3c, d and Supplementary Fig. 3k, l). This evidence concerns the gene SIRT5 and colorectal carcinoma.