Indeed, the tumor tissues derived from HA-9104-treated mice had increased NOXA levels, enhanced cleavage of PARP (apoptosis) (Fig. 6d), reduced staining of UBE2F (target), Ki67 (proliferation), and increased staining of γH2AX (DNA damage) (Fig. 6e, f). The gene discussed is PMAIP1; the disease is neoplasm.