Indeed, HA-9104 treatment significantly inhibited NOXA polyubiquitination (Fig. 3a, Supplementary Fig. 3a) and prolonged NOXA half-life (Fig. 3b, c, Supplementary Fig. 3b, c) with no or moderate effect on NOXA mRNA in all three lung cancer cell lines tested (Supplementary Fig. 3d). This evidence concerns the gene PMAIP1 and lung cancer.