PMAIP1 and lung carcinoma: Indeed, HA-9104 treatment significantly inhibited NOXA polyubiquitination (Fig. 3a, Supplementary Fig. 3a) and prolonged NOXA half-life (Fig. 3b, c, Supplementary Fig. 3b, c) with no or moderate effect on NOXA mRNA in all three lung cancer cell lines tested (Supplementary Fig. 3d).