LRRC8A and breast carcinoma: To this end, luciferase- and GFP-labeled SC, NHE1-KD, SWELL1-KD, and dual NHE1/SWELL1-KD MDA-MB-231 breast cancer cells were subcutaneously injected into the 4th mammary fat pad of NOD-SCIDγ (NSG) mice.