PDZK1IP1 and colorectal carcinoma: One SE, associated with the gene PDZK1IP1, ranked second out of 2026 SEs for recurrence in CRC, meeting ROSE criteria for SE calling in 12 out of 15 primary CRC tumors, 1 out of 15 patient-matched normal colon epithelia, and 0 out of 13 CRC cell lines (H3K27ac signal log2 fold change −2.07, P = 1.7e10−6; Figs. 3a, b and S4a).