The association of the genetic variants selected as instrumental variables for four proteins (TFPI, TMPRSS5, CD40 and CD6) colocalized with the stroke associations (posterior probability (PP) ≥0.7) (Supplementary Data 8 and Supplementary Fig. 2) i.e. the associations in these regions were likely due to the same underlying causal variants. Here, TMPRSS5 is linked to Stroke.