Based on genetic data for 308 proteins involved in cardiovascular disease, inflammation and neurological processes from ~5000 individuals21, our study provides robust evidence that six proteins (TFPI, TMPRSS5, CD40, MMP12, IL6RA and CD6) are causally associated with stroke and four of them showed genetic colocalization evidence with stroke outcome(s). This evidence concerns the gene TMPRSS5 and cardiovascular disorder.