RTEL1 and cancer: RTEL1 deficiency raises conflicts between the replication and transcription machinery due to defective G4s unwinding,33, 34, 35, 36 causes spontaneous DNA damage, short telomeres, telomeric aberrations, anaphase bridges,6 and complex chromosomal rearrangements, such as chromothripsis, all of which may lead to genomic instability and cancer development.46