STAT3 and cancer: The suppression of ABCA3 with siRNA or indomethacin inhibits the biogenesis of exosomes, which increases the intracellular retention of drugs, shifts the subcellular drug accumulation to prolong nuclear retention, and enhances the sensitivity of cancer cells to DOX and pixantrone.[239] In addition to ABCA3, some potent oncoproteins, such as STAT3, also regulates EV biogenesis and secretion.