Moreover, exosomes from NSCLC cells transfer lncRNA SOX2 overlapping transcript (SOX2‐OT) to macrophages to promote M2 polarization by targeting the miR‐627‐3p/Smads signaling pathway, which in turn enhances EGFR‐TKI resistance in NSCLC cells.[134] TMZ‐associated lncRNA in GBM recurrence (lnc‐TALC) is enriched in GBM cells derived exosomes and transmitted to promote M2 polarization of the microglia. Here, SOX2 is linked to non-small cell lung carcinoma.