STAT3 and glioblastoma: For example, TAMs transfer miR‐27a‐3p, miR‐22‐3p, and miR‐221‐3p into glioblastoma stem cells through exosomes, inducing radiotherapy resistance by targeting CHD7 and regulating RelB/P50 and STAT3 pathways to trigger proneural‐to‐mesenchymal transition.[181] Exosomal miR‐365 from TAMs also contributes to GEM resistance in PDAC by upregulating the pool of triphospho‐nucleotide and inducing the expression of enzyme cytidine deaminase.[182] Moreover, TAM exosomes derived miR‐223 and miR‐21 induce cisplatin resistance in gastric cancer and ovarian cancer, respectively.[183]