Zhang et al. suggest that circUHRF1 is enriched in HCC cells derived exosomes and upregulates the expression of TIM‐3 via sponging miR‐449c‐5p, leading to resistance to anti‐PD1 immunotherapy.[136] Hong et al. show that circ‐CPA4 regulates drug resistance in NSCLC by targeting let‐7/PD‐L1 axis. Here, CD274 is linked to non-small cell lung carcinoma.