Restoration of miR‐151a in TMZ‐resistant cells through exosomal delivery inhibits XRCC4‐mediated DNA repair and increases therapy sensitivity.[270] Exosomal delivery of miR‐146a increases ovarian cancer cell sensitivity to docetaxel and PTX by regulating LAMC2/PI3K/Akt axis.[271] Exosome‐delivered miR‐122 increases the sensitivity of HCC cells to soferanib by downregulating multiple resistance‐related genes and inducing apoptosis and cell cycle arrest.[272]. This evidence concerns the gene AKT1 and ovarian carcinoma.