demonstrate that HOTAIR is present in serum EVs of GBM patients and EVs derived HOTAIR confers TMZ resistance by regulating miR‐526b‐3p/EVA1 axis.[118] In breast cancer, EVs transport lncRNA NEAT1 to upregulate KLF12 expression by sponging miR‐141‐3p, thereby promoting resistance to drugs such as cisplatin, PTX, and 5‐FU.[119] Kwok et al. Here, HOTAIR is linked to breast carcinoma.