PKM and non-small cell lung carcinoma: Wang et al. demonstrate that exosomes from oxaliplatin‐resistant CRCs transfer circular RNA hsa_circ_0005963 (also termed as ciRS‐122) to sensitive cells to enhance glycolysis and drug resistance by regulating miR‐122/PKM2 axis.[139] In addition, hsa_circ_0002130 is found to be upregulated in serum exosomes of osimertinib‐resistant NSCLC patients.