AKT1 and cancer: Hypoxic exo‐miR‐301a targets TCEAL7 to activate Wnt/β‐catenin signaling, thus promoting radiation resistance.[205] Exosomal miR‐21 derived from hypoxic NSCLC cells promotes the resistance of normoxic cells to cisplatin by downregulating PTEN.[206] MiR‐223 is enriched in TAM exosomes in response to hypoxia and internalized by ovarian cancer cells to induce a chemoresistance phenotype through the PTEN‐PI3K/Akt pathway.[183b] Therefore, hypoxia promotes the release of EVs with specific cargos to mediate drug resistance in cancer.