CA1 and diffuse large B-cell lymphoma: EVs from EnzaR cells endow the sensitive cells resistance to enzalutamide, which is abolished when YAP1 is depleted by siRNA, suggesting that YAP in EVs is a key factor in the acquisition of enzalutamide resistance.[71] Exosomal CA1 (carbonic anhydrase 1) level is higher in chemoresistant diffuse large B cell lymphoma (DLBCL) cells than its chemosensitive counterparts.