Li et al. have utilized BMSCs to deliver siGRP78 and revealed that exosomal delivery of siGRP78 enhances the sensitivity of drug‐resistant HCC cells to sorafenib.[264] In addition, exosome‐mediated delivery of siRNA efficiently silences circRNA‐SORE in HCC cells, which promotes PRP19‐mediated degradation of YBX1 and significantly increases sorafenib‐induced apoptosis.[142]. The gene discussed is PRPF19; the disease is hepatocellular carcinoma.