CD8A and non-small cell lung carcinoma: Circ‐CPA4 knockdown reactivates CD8+ T cells and promote NSCLC cell death.[137] Chen et al. demonstrate that NSCLC cells derived circUSP7 sponges miR‐934 to upregulate SHP2 (src homology region 2‐containing protein tyrosine phosphatase 2) expression, thereby inhibiting CD8+ T cell function and promoting resistance to anti‐PD1 immunotherapy.[138]