BIRC5 and pancreatic adenocarcinoma: Aspe et al. have used exosomes to deliver Survivin‐T34A, a dominant‐negative mutant of survivin that induces caspase activation and cell apoptosis by dissociating caspase‐9/survivin protein complex.[255] Exosomes collected from engineered cells contain Survivin‐T34A and significantly increase GEM‐induced apoptotic cell death, suggesting that the delivery of Survivin‐T34A by exosomes enhances GEM sensitivity in pancreatic adenocarcinoma.